Separation of natural CD1c + cDCs (cDC2s) and BDCA4+ pDCs from human leukapheresis products without the need for fluorescence-activated cell sorting and in good manufacturing practice (GMP) conditions was already achieved [16, 17] and technological advances will hopefully soon make GMP isolation of human BDCA3+ cDC1s possible (PROCROP Cancer Immunotherapy European Initiative Web Site. This evidence concerns the gene THBD and cancer.