Human cDC1s (DNGR-1/CLEC9A+, XCR1+) and their mouse equivalents (DNGR-1/Clec9a+, Xcr1+, also expressing CD8 in lymphoid organs) are strong inducers of CD8+ T cell responses due to their superior capacity for uptake of dying or dead cell material and processing of cancer cell-associated Ags for cross-presentation [18–22]. Here, XCR1 is linked to cancer.