Indeed, tumor-bearing mice treated with cDC1s exhibited larger tdLNs, and the number and frequency of PD-1-expressing CD44+ activated CD8+ and CD4+ T cells and H-2Kb- OVA257–264+ CD44+ CD8+ OVA-specific T cells was significantly enhanced in the tdLNs, while CD44+ OVA-specific CD4+ T cells remained unaltered (Fig. 5e & h and Additional file 1: Figure S4a-c, f-h, k & l). Here, CD4 is linked to neoplasm.