Since we previously clarified that down-regulation of ErbB2 and ErbB3 in breast cancer cells was attributed to induction of ErbB2- and ErbB3-targeting miRNAs (miR-125a, miR-125b, and miR-205) by HDACi entinostat [24], we then asked whether similar mechanisms might account for VPA-induced down-regulation of the ErbB family members in pancreatic cancer cells. The gene discussed is ERBB2; the disease is familial pancreatic carcinoma.