To explore whether VPA might show any therapeutic effect on pancreatic cancer, we investigated its anti-proliferative/anti-survival activities in the EGFR/ErbB2/ErbB3-coexpressing (HPAF-II, MPanc96) and ErbB3-negative (MiaPaca-2, Panc-1) pancreatic cancer cell lines (Fig. 1a). This evidence concerns the gene ERBB2 and familial pancreatic carcinoma.