TP53 and familial pancreatic carcinoma: Recently, VPA was also evidenced to synergize with capecitabine and radiotherapy in colorectal cancer via modulation of both wild-type and mutant p53 [48], and both VPA and Trichostatin A (TSA) were shown to induce pancreatic cancer cell apoptosis and autophagy by Gilardini Montani et al. [49].