The favorable outcomes of mGluR5 blockade in the zQ175 model of HD and both the APPswe/PS1ΔE9 and 3xTg-AD models of Alzheimer’s disease were associated with increased autophagy via alterations in Zinc finger and BTB domain-containing protein 16 (ZBTB16)- and Unc-51-like kinase 1 (ULK1)-dependent mechanisms [10, 13]. This evidence concerns the gene GRM5 and Alzheimer disease.