PADI4 and Sepsis: Pediatric septic patients exhibited significantly (P < 0.001) higher levels of Padi4 expression in circulating neutrophils than that of the healthy controls, and there was a positive correlation between the level of serum NETs and the risk of mortality by sepsis in pediatric (Log-PRISM score) (Fig. 5b and Additional file 14: Figure S12E) and in adult patients [39].