There were seven pathways containing IL1B and CCL2, according to the KEGG analysis, including rheumatoid arthritis, cytokine-cytokine receptor interaction, TNF signaling pathway, the IL-17 signaling pathway, the AGE-RAGE signaling pathway in diabetic complications and malaria, atherosclerosis and fluid shear stress. The gene discussed is CCL2; the disease is rheumatoid arthritis.