Following adjustment for variety clinical pathological factors and social economic factors, we confirmed that cigarette smoking [95% confidence interval (CI), 0.831–2.727, hazard ratio (HR): 1.506; P = 0.020], diabetes mellitus (95% CI, 1.634–8.283, P = 0.002 for HR: 3.679), and the overexpression of serum IL1B (95% CI, 1.435–2.845, P = 0.017 for HR: 1.896) and CCL2 (95% CI, 0.563–2.440, P = 0.032 for HR: 1.172) genes were still considered independent predictors for CAD. This evidence concerns the gene IL1B and coronary artery disorder.