For example, oncogenic ABL1 and 2 kinases have been observed to be overexpressed or hyperactivated in NSCLC [89, 90] and are also involved in the tumor growth and metastasis of lung cancer experimental models, which have recently been demonstrated to be regulated to some extent, via the role of TAZ and β-catenin by inhibiting their binding Β-TRCP, which increases their stability [88]. This evidence concerns the gene WWTR1 and non-small cell lung carcinoma.