Notably, KHDRBS2, RALYL, SLC25A21, THSD7B, EPHA3, ESR1, EPHA6, HBE1, and HLX have been implicated in brain tumors [28–39], whereas PCDHGA2, PCDHGA3, and MTUS2 have known relationships to other types of cancer [40, 41]. The gene discussed is ESR1; the disease is cancer.