From this ranking, we identified many bivalent domains with significant discordance in DNA methylation, with the most highly ranked domains being associated, for example, with ZNF467, PCDH8, ISLR2, HLX, NR2E1, WT1, AGAP2, TGFB1I1, LRFN1, KLF4, and SOX10, which have been previously implicated in brain tumors [39, 49–58]. The gene discussed is PCDH8; the disease is brain neoplasm.