From this ranking, we identified many bivalent domains with significant discordance in DNA methylation, with the most highly ranked domains being associated, for example, with ZNF467, PCDH8, ISLR2, HLX, NR2E1, WT1, AGAP2, TGFB1I1, LRFN1, KLF4, and SOX10, which have been previously implicated in brain tumors [39, 49–58]. This evidence concerns the gene HLX and brain neoplasm.