PTK2 and cancer: In summary, our present study reveals that PBN11-8 is able to significantly inhibit the growth of cancer cells, and inhibit adhesion, migration, and invasion by disturbing the integrin/FAK/ERK signal transduction and reducing MMP-2 and MMP-9 in BEL-7402 cells, and that the inhibitory effect of PBN11-8 on cells is highly associated with FAK expression.