CDHA–MGO possesses the following important features: (1) High loading efficiency of antitumor drug DOX for chemotherapy, (2) easy separation and magnetic targeting properties with an external magnetic field, (3) high NIR absorption and efficient heat transformation for photothermal therapy, (4) CD44-targeting for accumulation within tumor cells via HA conjugation, and (5) controlled release characteristics including NIR/heat-stimulation and pH-responsive. This evidence concerns the gene CD44 and neoplasm.