Dietary MG significantly suppressed atherosclerotic lesions in the Apoe−/− mice and was associated with decreased serum total cholesterol (chylomicron remnants and VLDL) and triglyceride levels, decreased hepatic HMG-CoA synthase and Fatp, and increased serum LPL activity, in addition to strong attenuation of hepatic steatosis. Here, HMGCS2 is linked to fatty liver disease.