Using a specific breeding scheme (Ifnar1−/− dams mated to Ifnar+/− sires) and intravaginal infection, Yockey et al. showed that fetuses that expressed IFNAR (Ifnar1+/−) were resorbed after ZIKV infection during early pregnancy despite relatively lower viral titer in their placentas, whereas their Ifnar1−/− littermates that did not express IFNAR continued to develop. Here, IFNAR1 is linked to Zika virus infectious disease.