Fucoxanthin anti-obesity activity has been attributed to the stimulation of thermogenesis by increasing the expression of uncoupling protein 1 (UCP1) in adipose tissues [16,17,20] as well as to effects on intestinal lipid absorption and lipid metabolism [17,20,21,22,23]. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.