Lu et al., who developed an intracellular-labile amphiphilic CUR-based micelles delivery system (CUR-PEG), observed a highly significant inhibition of tumor growth matched with a strong CTL response and high amounts of IFN-γ when this polyphenol micelles were administered in combination with lipid/calcium/phosphate (LCP) Trp2-based vaccine to treat B16F10 advanced melanoma in C57BL/6 mice [95]. The gene discussed is IFNG; the disease is melanoma.