TNF and neoplasm: More conclusive are, instead, the results from Lu et al. who, in the CUR-vaccine model (CUR-PEG + LCP-Trp2) of mice challenged with B16F10 melanoma cell line, evaluated cytokines levels in the tumor microenvironment and found a significant decrease of IL-6 and CCL2 and a dramatic increase in TNF-α and IFN-γ levels, helpful cytokines in the establishment of a cytotoxic T cell-mediated response [95].