Finally, recent evidence on EGCG suggest a significant anti-proliferative and immunosuppressive effect on PBMCs isolated from newly diagnosed breast cancer patients or age matched controls stimulated with PHA, anti-CD3, or Her2/neu and p53 antigen peptides [80], further implying that polyphenol effects in vivo are compound-, dose- and cell-specific. The gene discussed is ERBB2; the disease is breast cancer.