Through inhibition of the calcium-dependent signalling events in the calcineurin/NF-AT pathway, dipyridamole was found to reduce the activation and proliferation of double-negative T cells (DNTC) and associated production of the proinflammatory cytokines IFN-γ, IL-6 and IL-17 in lupus-prone MRL/lpr mice. This evidence concerns the gene IFNG and systemic lupus erythematosus.