The phase III randomized clinical study including 726 postmenopausal women with ER-positive HER2-negative advanced breast cancer, named MONALEESA-3, showed that the addition of ribociclib to fulvestrant significantly improved median PFS from 12.8 months in the placebo group to 20.5 months in the ribociclib group (HR, 0.59; 95% CI, 0.48 to 0.73; p < 0.001) [50]. Here, ERBB2 is linked to breast cancer.