On the other hand, a combined effect of anti-PD-L1 mAb and LY364947 was not observed in poorly immunogenic KPC1 tumor model; blocking of TGF-β resulted in significant reduction of KPC1 tumor outgrowth, in contrast to the anti-PD-L1 mAb-treated group, which was not effective in this model. This evidence concerns the gene RNF123 and neoplasm.