APOA4 and atherosclerosis: To date, apoA-IV is known to participate in a broad spectrum of biological processes, including lipid metabolism [5,6,7], reverse cholesterol transport [8,9,10], protection against atherosclerosis [11,12,13], platelet aggregation and thrombosis [14], glucose hemostasis [15,16,17,18], as well as food intake [19,20].