IFNG and chronic rhinosinusitis without nasal polyps: Tan et al. [39] reported no significant difference in IFN-γ levels in a controlled study comparing only ethmoid tissue of healthy, CRSsNP and CRSwNP patients, unlike previous work in their lab [40] and other published data [35,36] which compared IFN-γ levels between healthy, CRSsNP and CRSwNP patient cohorts, each with different tissue sample sites.