In the clinical setting of patients with initial diagnoses of thyroid cancer who are being evaluated for suspicious LNs before surgery, who had contralateral remnant lesions after lobectomy, or who are candidates for the evaluation of recurrent LNs with unrecognized remnant tissue during cancer surveillance after initial treatment, only washout Tg measurement for the diagnosis of metastatic LNs may miss several suspicious cases, when FNAC results are incomplete. This evidence concerns the gene TG and cancer.