The DGF-out conformation was later found for EGFR’s kinase domain, for example, in the crystal structure of the complex between the EGFR kinase domain displaying the inactivating V924R mutation and an inhibitory mitogen-inducible gene 6 (MIG6) peptide [37], a negative regulator of EGF receptor-mediated skin morphogenesis and tumour formation, also known as RALT or Gene 33 [149]. This evidence concerns the gene EGFR and neoplasm.