PPARGC1A and colorectal carcinoma: Taken together, this study indicates that PGC-1α regulates the mitochondrial function and 5FU resistance in 5FU-resistant CRC cells through the inhibition of 5FU-mediated ER stress and apoptosis, suggesting that the targeting of PGC-1α might be a novel therapeutic strategy in combination with 5FU chemotherapy to combat 5FU-resistant CRC cells.