PPARGC1A and colorectal carcinoma: However, the silencing of PGC-1α significantly decreased the mitochondrial mass, the activities of mitochondrial complex I and IV, and the oxygen consumption ratio in the SNU-C5/5FUR cells after treatment with 5FU (Figure 2C–F), indicating that PGC-1α is involved in the mitochondrial functionality in the 5FU-resistant CRC cells against treatment with 5FU.