For instance, the genomic region of chr11:110,716,521–110,832,306 in diffuse large B-cell lymphoma (DLBCL) acts as an enhancer that specifically regulates POU2AF1 [12], and the genomic region of chr22:27,552,905–27,512,763 acts as an enhancer with activating expression of XBP1 in the multiple myeloma cell line (MM1.S) [13]. The gene discussed is XBP1; the disease is diffuse large B-cell lymphoma.