Interestingly, nine identical closely related proteins (MX1, IFIT1, IFIT3, ISG15, DDX58, STAT1, OAS3, EIF2AK2 and SAMHD1) were up-regulated in both infection models and, with the exception of SAMHD1, all were interconnected in the functional network (Figure 1C). The gene discussed is RIGI; the disease is infection.