In contrast, the hypoxia‐inducible factor HIF‐1α, which has been revealed as a master regulator of the stemness properties of cancer stem cells (Mimeault and Batra, 2013), is increased in HepG2SF1 and Huh7 cells compared with their parental cells and decreased in AMPK‐transfected cells. Here, HIF1A is linked to cancer.