The recipient was a 53 years old caucasian male with Hepatocellular Carcinoma fulfilling Milan criteria after two trans arterial chemo embolization (TACE) with underlined HCV- cirrhosis (biochemical MELD 7) who consented for NMP; alpha-fetoprotein (AFP) level at listing was 5.72 UI/ml, balance of risk (BAR) [7] was 4. The gene discussed is AFP; the disease is hepatocellular carcinoma.