Our results indicate that the upregulation of the cGMP/PKG/p65 signaling reduces CCL5 secretion in CD8+ T cells, which in turn decreases the proliferation of BECs in low androgen conditions, suggesting that the combination of 5α reductase inhibitors lowering androgen levels and PDE5‐Is may be a novel, more effective treatment for BPH patients. Here, PDE5A is linked to benign prostatic hyperplasia.