A number of clinical trials have shown that PDE5‐Is used for the treatment of pulmonary arterial hypertension and erectile dysfunction24, 25, 26, 27 could effectively ameliorate LUTS associated with BPH.3, 4, 5 The main effect of cGMP/PKG signaling pathway associated with PDE5‐Is is considered to relax smooth muscle in the prostate.6 Moreover, Vignozzi et al11, 14 found that PDE5‐Is could inhibit inflammation levels in overall prostate, and we also considered that activation of the cGMP/PKG signaling pathway plays a role in inflammation. The gene discussed is PRKG1; the disease is pulmonary arterial hypertension.