The criteria of prostatic hyperplasia contained the layer number of epithelial cells and the protruding crest measured by hematoxylin and eosin staining, also including the weight of rat prostates (P < 0.001 for groups by t test, control vs HFD, and HFD vs HFD + PDE5‐Is; Figure 4C). Here, PDE5A is linked to prostate disorder.