HOTTIP and cancer: In each of these cancers, increased expression of HOTTIP is associated with increased expression of HOXA13 in vitro, leading to increased proliferation and migration.[44–50] This locus was investigated in our previous study and contained only a single significant eQTL signal, HOTTIP.[33] Unsurprisingly, 33% of the top 100 eQTL variants (those with the smallest FDR q-value) were shared between TAX1BP1 and HOXA13, while 16% were shared between both the protein coding genes and the lncRNA HOTTIP.