HOTTIP and Familial prostate cancer: Interestingly, the lncRNA HOTTIP (Fig 2C), a Group 3 eQTL signal, is also a significant signal at this locus and it can regulate the expression of distal HOX genes, such as HOXA13, through binding WDR5 and promoting H3K4me3 over the HOXA locus.[43] Expression of HOTTIP is increased in several cancer types compared to their normal cellular counterpart, including esophageal, gastric, non-small cell lung, pancreatic, and prostate cancer.