Eph receptors (Ephs) are the largest family of receptor tyrosine kinases with fourteen receptors divided into two subfamilies (EphAs and EphBs); these receptors are associated with angiogenesis and tumor vasculature in various human cancers.9 EphA3 is highly expressed in the brain, kidneys, heart, and lungs during embryonic development and then declines to a low level in adults. Here, EPHA3 is linked to neoplasm.