The SNP in the RASD1-PEMT-RAI locus that is associated with CAD is not associated with various vascular-related traits (Schunkert et al., 2011); yet it is associated with ischemic stroke, with the same direction of effect (Dichgans et al., 2014), suggesting a potential role for oxygen deprivation. This evidence concerns the gene PEMT and coronary artery disorder.