For example, in an AD patient iPSC-derived 3D culture system, amyloid and Tau pathology were significantly reduced after treatment with β- and γ-secretase inhibitors [116,126]; however, Lee et al. [126] indicated that β- and γ-secretase inhibitors work more effectively in decreasing Aβ levels in AD-NPCs-derived 2D neurons than in 3D spheroids [132]. This evidence concerns the gene MAPT and Alzheimer disease.