PRKN and Parkinson disease: About 10% of PD cases are caused by inherited genetic mutations; most of the responsible genes are involved in regulation of mitochondrial function and oxidative stress, including SNCA (α-synuclein) [5,29], PARK2 (Parkin) [66], PINK1 (PTEN-induced kinase 1) [67], PARK7 (protein deglycase DJ-1), LRRK2 (leucine-rich repeat kinase) [67–69] and ATP13A2 (ATPase type 13A).