A total of 9936 CRC patients and 7935 healthy controls were included in this study, and the results showed that the concentrations of CEA and CA19-9 were both elevated in the CRC group and significantly different from the healthy control group (p < 0.001 and p = 0.004, respectively), indicating that CEA and CA19-9 were capable for CRC detection. This evidence concerns the gene CEACAM5 and colorectal carcinoma.