PRMT5 and glioma: G2/M arrest was previously observed in U‐87 MG human glioma cells36 treated with EPZ015666, and in NIH‐3T3 cells stably expressing an anti‐sense PRMT5.9 Some studies have shown that following PRMT5 knockdown, Huh7, MCF‐7, and MDA‐MB‐231 cells also exhibit decreased proliferation, but associated to a G1/S growth arrest.12, 25, 37 The mode of PRMT5 targeting is likely determinant here.