PRMT5 and cancer: In contrast, PRMT5 depletion impairs the viability of all the TNBC cell lines tested in this study, thus aligning with previous research conducted on cell lines derived from other cancer types10, 34 or on MDA‐MB‐46816 and another TNBC‐derived cell line, MDA‐MB‐231.8, 25 It thus appears that the effect of PRMT5 depletion on cell viability is independent from cell sensitivity to EPZ015666.