ERBB2 and breast cancer: We examined the expression of PRMT5 in a previously generated cohort of 150 breast cancer biopsy specimens and normal breast tissues from the Institut Curie Hospital (Curie cohort).17 We find that TNBC express similar levels of PRMT5 mRNA compared to luminal breast cancers and healthy breast tissues, and higher levels of PRMT5 mRNA compared to HER2 + breast cancers (Figure 1A, left panel).