Trx1 is a 12‐kDa protein that regulates signaling molecules in redox‐regulated gene pathways.44, 45, 46, 47 Trx1 is a cytosolic thiol antioxidant and redox‐active protein that plays a vital role in maintenance of the intracellular redox state.48 There is some evidence that Trx1 is involved in the pathogenesis of cardiovascular diseases, including hypertension. The gene discussed is SPRR2A; the disease is hypertensive disorder.