Trx1 is a 12‐kDa protein that regulates signaling molecules in redox‐regulated gene pathways.44, 45, 46, 47 Trx1 is a cytosolic thiol antioxidant and redox‐active protein that plays a vital role in maintenance of the intracellular redox state.48 There is some evidence that Trx1 is involved in the pathogenesis of cardiovascular diseases, including hypertension. Here, SPRR2A is linked to Hypertension.