The human gene encoding D5R, the DRD5 locus at 4p15.1 to 16.1, is associated with essential hypertension12, 13 and metabolic syndrome, of which hypertension is a component.43 Single‐nucleotide polymorphisms in, and duplications of, the DRD5 gene have been found in humans,21, 22, 23 and carriers of the hD5RF173L mutation have a decreased ability to stimulate cAMP production.17, 24 Therefore, to investigate the role of D5R in the elaboration of hypertension, we generated hD5RF173L‐TG and hD5RWT‐TG mice. This evidence concerns the gene DRD5 and metabolic syndrome.