Activity of dopamine receptors is regulated by phosphorylation/dephosphorylation.5, 6, 7, 25, 26, 53 In hypertension, uncoupling of D1R from its G protein/effector complex in RPT is caused, in part, by increased D1R phosphorylation25, 26, 53 that impairs D1R function, increases production of second messengers, and inhibits the activity of sodium transporters/pump.4, 5, 6, 7 Until now, the roles of phosphorylation and uncoupling of D5R from its G protein/effector complex in the development of hypertension have not been studied. This evidence concerns the gene DRD1 and hypertensive disorder.