For example, Trx1 mRNA levels are increased in mononuclear cells from hypertensive humans, but are decreased after 3 months of antihypertensive treatment.49 Angiotensin II–induced high blood pressure has been associated with a 3‐fold increase in cardiac Trx expression in mice.50 However, Trx expression is decreased in aorta, heart, and kidney of the spontaneously hypertensive rat relative to the normotensive Wistar–Kyoto rat. Here, AGT is linked to hypertensive disorder.