Humans carry single‐nucleotide polymorphisms in the DRD5 gene, some of which confer diminished D5R function and abnormal coupling with adenylyl cyclase.21, 22, 23 The human D5R F173L (hD5RF173L) mutation markedly impairs stimulation of cAMP production.17, 24 To investigate the role of hD5RF173L in the elaboration of hypertension, we generated hD5RF173L transgenic (hD5RF173L‐TG) and hD5R wild‐type transgenic (hD5RWT‐TG) mice. Here, DRD5 is linked to hypertensive disorder.