The human gene encoding D5R, the DRD5 locus at 4p15.1 to 16.1, is associated with essential hypertension12, 13 and metabolic syndrome, of which hypertension is a component.43 Single‐nucleotide polymorphisms in, and duplications of, the DRD5 gene have been found in humans,21, 22, 23 and carriers of the hD5RF173L mutation have a decreased ability to stimulate cAMP production.17, 24 Therefore, to investigate the role of D5R in the elaboration of hypertension, we generated hD5RF173L‐TG and hD5RWT‐TG mice. The gene discussed is DRD5; the disease is Hypertension.