HDAC4 and gestational diabetes: AMPK activation (Figure 3(A)) attenuated (nearly 60%) in GDM mice (p < 0.05), contributing to higher HDAC4 activation (about 2.5-fold) (Figure 3(B)) (p < 0.05), which could further up-regulate G6Pase expression (about 3.2-fold) (Figure 3(C)) (p < 0.05).