EGFR and neoplasm: As shown in Figure 5(C,D), after treatment of CF-NP-EB/DAPT, the levels of EGFR and Notch in tumor cells were obviously down-regulated while not for those cells treated by NP-EB/DAPT, indicating a good EGFR and Notch signaling inhibition effect for the peptides-modified nanoparticles.