Previously Kim and colleagues reported that EYA4 acts as a new tumour suppressor gene in colorectal cancer and its expression was down‐regulated in HCT15 colorectal cancer cells overexpressing EYA4.12 As a transcription factor, c‐JUN functions as an upstream regulator of many genes, including VEGFA and participates in tumour growth and metastasis.20, 21 Since EYA4 possessed the N‐terminal serine/threonine‐specific phosphatase activity,7 it was hypothesized that EYA4 down‐regulated c‐JUN via dephosphorylation. This evidence concerns the gene ENSG00000280371 and neoplasm.