First, despite near-complete variant ascertainment in a modest-size European ancestry sample, only one low-frequency variant (a previously reported noncoding variant in CCND2 [47]) achieved genome-wide significance, enabling quantitative bounds on the T2D effect sizes of low-frequency variants, which, in short, rejected models proposing a significant number of low-frequency strong-effect T2D variants. The gene discussed is CCND2; the disease is type 2 diabetes mellitus.