ROC analysis revealed a significant difference in GGO volume percentage in adenocarcinomas with exon 21 missense and EGFR mutation compared with tumors without EGFR mutation (p < 0.001, area under the curve=0.871, sensitivity=94.6%, specificity=73.8%, and p < 0.001; area under the curve=0.783, sensitivity=69.9%, specificity=75.4%, resp). This evidence concerns the gene EGFR and adenocarcinoma.