IGF1 and Other metabolic disease: Among the total 20 canonical pathways, Nrf-2-mediated oxidative stress response, TGF-β signaling, and B cell receptor signaling are strongly associated to chronic inflammation; metabolism of xenobiotics by cytochrome P450, bile acid biosynthesis, C21-steroid hormone metabolism, glycerophospholipid metabolism, glycerolipid metabolism, glutamate metabolism, IGF-1 signaling, and fatty acid metabolism are closely linked to metabolic disease, especially glucolipid metabolism dysfunction.