In the past, ICC would be misdiagnosed as metastatic disease from another primary or CUP due to the fact that ICC share many of the same immunohistochemistry (IHC) with other cancers, such as staining positive for cytokeratin (CK) seven and CK19 and negative staining for CK20 [1, 13]. The gene discussed is KRT19; the disease is intrahepatic cholangiocarcinoma.