We have previously shown that the number and grade of pancreatic intraepithelial neoplastic lesions in Pdx cre-Kras+/G12D mice were significantly reduced in animals treated twice-daily with 200mg/kg RGS and that the decrease in tumor grade and burden correlated with inhibition of RAS-driven signaling and the induction of apoptosis [6]. This evidence concerns the gene KRAS and neoplasm.