EGFR and neoplasm: We also performed immunohistochemical analysis on 502 human cases covering 27 tumor types and studied the correlation between EGFR protein expression and clinical outcomes or pathological characteristics corresponding to membranous and cytoplasmic or nuclear expression pattern as explanatory variable due to the fact that granular EGFR expression in the nucleus has been described as a factor of resistance to chemo- and radiotherapy [8–10].