Silencing of IFNGR1 gene by shRNA abolished the PD-L1 upregulation in MM cells by IFN-γ in the presence or absence of panobinostat, indicating a critical role of IFN-γR1 in mediating intracellular IFN-γ signaling (Supplementary Figure 5B). This evidence concerns the gene IFNG and Miyoshi myopathy.