STAT1 gene silencing by shRNA mostly abolished the enhancement of PD-L1 expression at mRNA and protein levels in MM cells by panobinostat in the presence of IFN-γ at 24 hours (Figure 4C and Supplementary Figure 3B), although panobinostat alone was able to induce PD-L1 expression largely through histone acetylation of the PD-L1 gene promotor in the absence of IFN-γ. Here, CD274 is linked to Miyoshi myopathy.