As IRF1 protein levels decreased in MM cells by panobinostat in the presence of IFN-γ at 24 hours (Figure 3C and 3D), STAT1 upregulation and activation likely play an important role in the cooperative and stable upregulation of PD-L1 in MM cells by panobinostat and IFN-γ in combination. This evidence concerns the gene IFNG and Miyoshi myopathy.