We demonstrated that panobinostat alone upregulated cytotoxicity-associated molecules, including natural killer group 2D (NKG2D) ligands, UL16-binding protein-2/5/6 (ULBP2/5/6), and MHC class I chain–related proteins A and B (MICA/B) in MM cells in parallel with PD-L1 upregulation. Here, ULBP2 is linked to Miyoshi myopathy.