However, in parallel with the upregulation of the NKG2 ligands, the expression of PD-L1 on MM cells was found to be upregulated by panobinostat, which is further enhanced in combination with IFN-γ, although IFN-γ production is increased by ambient immune cells activated by immunotherapies in a tumor microenvironment. The gene discussed is CD274; the disease is neoplasm.