Analysis of tumor organoid cultures derived from SPC (Sftpc)-CreERT2; KrasLSL-G12D; Rosa26-tdTomato mice, showed that organoids from KRAS+ mice treated with the combination treatment of GNF5 and docetaxel had significantly higher expression of SPC compared to vehicle control-treated organoids from KRAS+ mice (Figure 3D-3E). The gene discussed is KRAS; the disease is neoplasm.