Moreover, primary lung adenocarcinoma cell lines derived from KrasLSL-G12D; p53fl/fl lung tumors also showed an increase in expression of differentiation markers (acetylated α-tubulin) and a decrease in expression of basal cell markers (Krt5) after co-treatment with GNF5 and docetaxel compared to vehicle control or single-agent treatment in vitro (Supplementary Figure 3B). The gene discussed is KRT5; the disease is lung adenocarcinoma.