For example, in a breast adenocarcinoma line with high metastatic potential, the effect of TIS21 tumor suppressor, which consists in inhibiting the formation of invadopodia and, therefore, blocking the invasion, is realized through a mechanism mainly based on activation of Akt1, while changes in Akt2 expression had no impact on invadopodia formation and invasive activity [38]. This evidence concerns the gene AKT2 and breast adenocarcinoma.