SLFN12 and cancer: de Waal et al. identified cancer-cytotoxic modulators of PDE3A by predictive chemogenomics and demonstrated in HeLa cells that the strong viability reduction observed in cancer cell lines with the non-catalytic inhibitor DNMDP, was induced by an original neomorphic interaction between PDE3A and the protein Schlafen 12 (SLFN12) [16].