RNF43 and acute lymphoblastic leukemia: In addition to the significant interaction effect detected between RGL1 and RAD51B, we also identified some interactions with consistent evidence across discovery and replication studies but not achieving significance threshold (p value < 1.95x10-10) in the overall meta-analysis, such as CD109:ESR1 gene pair in ALL cohort, THADA:PVT1 in NSCLC cohort, SYNE1:RNF43 from ADE cohort, and BRE:RUVBL1 and FHIT:TSPAN8 from SQC cohort (Table 2).