The pathway “hot spot” genes from ALL and NSCLC are EGF, FGFR2, EGFR, and GSK3B, etc. The regulation of the epithelial-mesenchymal transition (EMT) pathway is among the top 5 canonical pathways in both ALL (p = 1.79x10-5) and NSCLC (p = 6.02x10-3) lung cancer cohorts. The gene discussed is EGFR; the disease is lung cancer.