Interestingly, all the three significant epistasis—-RGL1:RAD51B in ALL and NSCLC lung cancer, SYNE1:RNF43 in ADE and FHIT:TSPAN8 in SQC risk development—-were displayed as interaction between networks (Figure 4 and Appendix 3 Supplementary Figure 2). The gene discussed is RNF43; the disease is acute lymphoblastic leukemia.