In addition to the significant between-network interactions in RAD51B:RGL1, SYNE1:RNF43 and TSPAN8:FHIT pairs, we also see within-network interactions, such as the interaction between THADA and PVT1 in the NSCLC cohort, and between BRCA1 and SYNPO2 in ADE cohort, etc (Figure 4A-4B). This evidence concerns the gene PVT1 and acute disseminated encephalomyelitis.