High LTBP2 protein expression was detected in 28.4% of CRC tissues, which was significantly higher compared with the expression detected in 4.3% of chronic colitis tissues, in 6.8% of low-grade intraepithelial neoplasia tissues, in 22.7% of high-grade intraepithelial neoplasia tissues, and in 6.8% of the surgical margin (Pearson χ2 = 39.896, P < 0.001) (Table 1). The gene discussed is LTBP2; the disease is intraepithelial neoplasia.