Further, its mechanism was investigated on 4T1 cells, and the results showed that verticine could regulate blood viscosity, improve blood flow state, reduce the expression of u-PA, VEGF, and PAI-1 protein and the secretion of IL-8, reduce the infiltration of neutrophils, improve TFPI-2 protein expression to promote tumor apoptosis, and inhibit angiogenesis and reduced cell transfer rate [8]. Here, VEGFA is linked to neoplasm.