Cho and coworkers found that MSCs from ALS patients showed a reduced expression of Oct-4 and Nanog and of the trophic factors ANG, FGF-2, HGF, IGF-1, PIGF, SDF-1α, TGF-β, and VEGF, but not BDNF or ECGF. Here, TGFB1 is linked to amyotrophic lateral sclerosis.